That's what I am, all by myself, while the better half attends to family business 1500 miles away. Might as well brew the solo-ness into a Contest ...
So make a comic about The Last Person On Earth. You must have one and only one human character, and that's who it is. Other than that, most anything goes; your protaganist can interact with animals, inanimate objects, whatever, for real, or in his/her imagination.
I'll judge sometime around a week and a half from now, around when the missus gets back.