I really hope somebody gets this one, considering how long I spent on it...
You're down to your last clip of ammo.
The charge has run out on your cyber implant.
You're all out of medical hypos.
Your psychic power is completely drained.
There's a security camera staring you in the face.
...and you can hear the distinctive sound of a cyborg assassin right around the corner...
You know what?

SHODAN SUCKS!
If you don't know who SHODAN is, you've missed one of the all-time great computer game villains, and two absolutely kick-arse games - System Shock and System Shock 2, made about eight years apart by the late and lamented Looking Glass Studios (who also made such classics as Thief 1 & 2 and Ultima Underworld 1 & 2).
This page has a very good pic of the look I was aiming for.