First off, mandingo and bigworm get the special prize (a bicycle helmet that's too small) for their contributions.
mandingo for this comic:
/comics/mandingo/527627/
and bigworm for his Poopacadoes (which are too numerous to post them all here).
Also a special mention to AA and biped for "Romulan Herpes" and "Gornian Slime-Whore Aids", respectively, with evil_d almost edging them out with "Spaceshiphillis".
But now the runners-up.
4th place goes to biped for "Balance of Error":
/comics/biped/528098/
I must admit that if I were an alien species that had never encountered humans, a naked Chicken dance would probably terrify me as well.
3rd place goes to RCColaman for "Bar Trek Drek":
/comics/RCCOLAMAN/528064/
This would have placed higher, but the mixing of genres (the captain speaking like Yoda) really threw me off. Excellent concept, though.
2nd place goes to evil_d for "Star Warts":
/comics/evil_d/528087/
It was a hard choice between this and the winner, especially with the clever pun-diseases and the almost-palindromic title.
But in the end 1st place, and CC487, goes to ZMannZilla and the following comic, which proves that even when disease is wiped out there will never be a cure for stupidity:
/comics/ZMannZilla/527631/
Take it away, Z!