anything. you bastards.

I would steer clear of making jokes out of the fact that your characters are "acting" in a comic and focus more on actual humour.

Also, you may aswell get the customery Exploding Dog "I think I'll hammer a nail into my head" comic out of the way.

The fourth wall was made to be broken!

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The 4th wall is where rotten tomatoes come from.

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I've broken the 4th wall many times, particularly in my Selling Out series, which I only mention because I like to promote myself.