Ed Norton as a nerdy nebbish little scientist who becomes big, angry and green? Sounds like a good fit to me. I have no issues with the casting of this movie, and actually want to see it.
Tobey Maguire as the skinny, acrobatic teenager Spider-Man? That works for me. The first two movies were gold. The third one would have been great if they didn't let Topher Grace talk while Venomed out. If you really have a problem with Brock being a skinny photographer, read some Ultimate Marvel sometime. It is an amalgamation of the mainstream and ultimate versions, as most Marvel movies lately have been.
Robert Downey Junior as the constantly drunk billionaire with a mechanized suit of armor? If you won't buy that, I can't imagine how you go grocery shopping. Iron Man was actually pretty awesome in my opinion.
X-Men was hit or miss. Casting Patrick Stewart as Xavier was a given. The rest of the cast was mostly well-rounded, though the heavy divergence from the original story started to grate on me a bit after a while. But it was made to get people to watch it, not for nerds like me to nod our heads in agreement with everything.
Coming up will be the Avengers movie. Marvel could make this awesome if they use a mix of classic Avengers and "New Avengers". Wolverene, the Hulk, Iron Man, Captain America, Vision and Hawkeye would make a good modern Avengers team. Obviously the Hulk, Wolverene and Iron Man are already cast. Filling in the role of Steve Rogers, some younger actor with the build and the "shit doesn't stick to him" look. No idea who that would be. The Vision's actor doesn't matter much, and could be done mostly through CGI like Iron Man. Hawkeye might be a bit of a pain in the ass to cast. Someone good at playing a cocky, mid-30s character would be nice. And then there's SHIELD director Nick Fury.
This will piss some people off. But it's pretty much assured. Samuel L. Jackson. Why? Sam L. is already the model for the Ultimates' Nick Fury. It seems weird, but that's how Marvel is likely to go.
Just imagine an exchange between Nick Fury and Tony Stark...
Stark: "Now let me ask you a question, Fury. When you drove in here, did you notice a sign out in front that said, "Dead mutant storage"?"
Fury: "Tony..."
Stark: "Answer the question! Did you see a sign out in front of my house that said "Dead mutant storage"?"
Fury: "Naw man, I didn't."
Stark: "You know why you didn't see that sign?"
Fury: "Why?"
Stark: "'Cause storin' dead mutants ain't my fuckin' business!"
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Do you want ants? Because that's how you get ants.