No need to ask, just go to it... only problem is that for some reason use of the "Splat" graphic in new comics was disabled at the last update. Too bad... I like the thought of non-bloody things making a bloody splat when they're shot. And no need to get anyone's pre-aproval for ideas either, because you never know what's going to be wildly funny until it's out there for everyone to see. Just make sure that *you* think the comics you make are funny. If you're a funny person, they probably are, and if not at least you have the powers of self delusion to fall back on. :)
The only thing most people here ask is that if you get inspired by one of their strips, give them credit somehow when you post it. I don't think anyone asked max if they could parody "Cowboy Physics," and that's got to be the most heavily spoofed strip on this site.