"46" in Japanese can be pronounced as "yon roku", and "yoroshiku"（よろしく） means "my best regards" in Japanese.  So, people sometimes use the number 46 as a greeting.  I've decided this will be the inspiration for RCD 46.  Your comic must use the following phrase:

"Give them my best regards"

No other rules, and I'll judge this as soon as there are enough entries.

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"He was cursed with a horrorshow of a face, like Guiseppe Archbold doing a study of mollusk tumors."

Bless You by four_legged_tripod 1-02-13

Hey man, you don't happen to have any Kleenex on you by chance, do ya? My wife might have some in her purse. Let me check. I'm holding it for her right now. Give them my best regards. Give who your best regards? Your balls. I'm assuming your wife keeps those in her purse as well.

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"Humiliation is humiliation only when you choose to suffer." ~ Chuck Palahniuk, Choke

RCD by HCRoyall 1-07-13

"Give them my best regards," she said. "Who?" I asked. "My little babies, when you get home," she said. Creepiest case of crabs I've ever gotten...

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It was such a waste of everyone’s time and money that even the Tokyo stadium’s rape robots apologized– something they were programmed specifically never to do.

I'm going to give this one until February then judge it no matter what.

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"He was cursed with a horrorshow of a face, like Guiseppe Archbold doing a study of mollusk tumors."

RCD 46: If Only They Had Google Translator by brycekain 2-02-13

Good news, Mein Führer! We have almost eliminated all the Jews and we used that old pit like you asked. Wait, what? You said "Gib ihnen meine besten grube." So we gave them your best pit. I said "Gib ihnen meine besten Grüße!" Give them my best REGARDS! Oh. Well this is awkward.

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...and if you liked that one, here's a link to my other stupid shit.

Only 3 entries, but I laughed at every single one, so I'm making a note here: HUGE SUCCESS.  Consider that an honorable mention for every person that entered this contest.

Unfortunately, there can only be one winner, and that winner, by the slightest margin, is brycekain. Take it away!

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"He was cursed with a horrorshow of a face, like Guiseppe Archbold doing a study of mollusk tumors."

This contest was rigged! I demand a recount! 

I... oh fuck it. I'll have a new one up soon.

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...and if you liked that one, here's a link to my other stupid shit.